Cell Stress Chaperones 15:605–617Ĭhen P, Burdette AJ, Porter JC, Ricketts JC, Fox SA, Nery FC, Hewett JW, Berkowitz LA, Breakefield XO, Caldwell KA, Caldwell GA (2010) The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response. Experts Rev Endocrinol Metabolism 5:681–695īurdette AJ, Churchill PF, Caldwell GA, Caldwell KA (2010) The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro. Invest Ophthalmol Vis Sci 49:2878–2887ĪIP (aryl-hydrocarbon receptor-interacting protein or aryl hydrocarbon receptor-associated protein 9, ARA9)Ĭain JW, Miljic D, Popovic V, Korbonits M (2010) Role of the aryl hydrocarbon receptor-interacting protein in familial isolated pituitary adenoma. Hidalgo-de-Quintana J, Evans RJ, Cheetham ME, van der Spuy J (2008) The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex. Proteins 80:1316–1325ĪIPL1 (aryl hydrocarbon-interacting receptor protein-like 1) Rekas A, Ahn KJ, Kim J, Carver JA (2012) The chaperone activity of α-synuclein: Utilizing deletion mutants to map its interaction with target proteins. doi: 10.1007/s0001-8Īnderssohn AM, Cox K, O’Malley K, Dees S, Hosseini M, Boren L, Wagner A, Bradley JM, Kelley MJ, Acott TS (2011) Molecular chaperone function for myocilin. Wyatt AR, Yerbury JJ, Berghofer P, Greguric I, Katsifis A, Dobson CM, Wilson MR (2011) Clusterin facilitates in vivo clearance of extracellular misfolded proteins. I really loved this film and thoroughly recommend it.Carver JA, Rekas A, Thorn DC, Wilson MR (2003) Small heat-shock proteins and clusterings: intra- and extracellular molecular chaperones with a common mechanism of action and function? IUBMB Life 55:661–668 As in previous Julian Fellows productions the attention to detail in costumes sets and direction are faultless. Haley Lu Richardson gives us a glimpse of why her determination and devil may care attitude propelled her to stardom but later sent her crashing to earth and virtual retirement in 1938 until much later her memoir Lulu in Hollywood published in 1982ģ years before she died caused such a renewed interest in her films and talent. Louise Brooks went on to become one of the most famous and at times infamous Silent movie Jazz Age Stars and this movie is only a snapshot of Louise before her Hollywood fame. I think this is the best role I've seen Elizabeth Mc Govern play we're so used to her famous role of Cora Crawley Countess of Grantham that this role as the Chaperone at times very dramatic and other times so touching and intelligent is a refreshing example of this actress and her range. The story is seen through the life experience of Norma ,who at first seems uncomplicated and sweet but as the story develops we soon know why Norma's not in Cherryville Kansas anymore. I really liked the way Julian Fellows has made The Chaperone Norma the main character rather than her much later famous ward Louise Brooks played beautifully by Haley Lu Richardson, recently also very impressive in Five Feet Apart. The Chaperone is such an interesting insight into the differences in attitudes, judgements and moral and racial prejudices of the early 1920's between 2 American cities Kansas and New York. Julian Fellows creator of Downton Abbey and 2002 Oscar Winner for Best Original Screenplay for Gosford Park is a master of storytelling and character development.
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